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| Product Name | Endonuclease G, Blocking Peptide (EndoG) |
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| Description | Purified 60-70%. Synthetic peptide (GGPRGPGELAKYGLP) corresponding to amino acids 55 to 70 of human EndoG (5). The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is speci?cally activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). EndoG is a mitochondrion-speci?c nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the ?rst mitochondrial protein identi?ed to be involved in apopto |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E2291-40P |
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| Order / More Info | Endonuclease G, Blocking Peptide (EndoG) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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