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| Product Name | MARK4, Recombinant, Human, GST-Tag (Microtubule Affinity-Regulating Kinase 4, MARKL1, KIAA1860) |
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| Description | Purified (~70-90%). MARK4 or microtubule affinity-regulating kinase 4 is a member of the Par-1 family of serine/threonine protein kinases. MARK4 is predominantly expressed in the brain and readily phosphorylates Tau, MAP2 and MAP4. MARK4 co-localizes with the centrosome and microtubules in cultured cells. Overexpression of MARK4 causes thinning out of the microtubule network concomitant with the reorganization of microtubules into bundles. MARK4 provides a growth advantage to cells and the up-regulation of this kinase during focal ischaemia may represent an interesting new target for pharmacological intervention. MARK4 is expressed during the cell cycle and is linked to aberrant centrosomes in glioma cells. Source: Recombinant protein corresponding to human MARK4, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~104kD Specific Activity: 1050nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_031417 |
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| Catalog # | 500234 |
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| Order / More Info | MARK4, Recombinant, Human, GST-Tag (Microtubule Affinity-Regulating Kinase 4, MARKL1, KIAA1860) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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