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| Product Name | FGF Beta-3 (TGFB3), Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Transforming Growth Factor Beta-3 is one of the isoforms of the highly pleiotropic cytokines that are secreted by all cell types. TGF Beta-1, TGF Beta-2, and TGF Beta-3 use the same receptor and act as cellular switches that regulate cell growth, proliferation, differentiation, motility, extracellular matrix synthesis, and immune function regulation. Defects of this gene can cause arrhythmogenic right ventricular dysplasia 1 and rienhoff syndrome. TGFB3 first interacts with the accessory receptor betaglycan (TGF Beta-R3) and a type II serine/threonine kinase receptor (TGF Beta-R2). The receptor then activates a type I serine/threonine kinase receptor such as ALK-1 or TGF Beta-R1 (ALK-5) through phosphorylation, and the activated type I receptor activates Smad proteins to regulate transcription. Recombinant TGF beta 3 is expressed from human 293 cells as a mature disulfide-linked homodimer with a molecular mass of 25kD. Source: Recombinant protein corresponding to human FGF Beta-3 expre |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P10600 |
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| Catalog # | 499985 |
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| Order / More Info | FGF Beta-3 (TGFB3), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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