| 产品详情 |
| Edit |   |
|---|
| Product Name | ASK1, CT, Blocking Peptide |
|---|
| Description | Purity ≥ 60%. Peptide (linear) corresponding to amino acids 1356-1375 of human ASK1 (1). This sequence is different from that of mouse by last two amino acids (3). Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5 (1-3). ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death. A catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues. |
|---|
| Size | 1mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | ASK1, CT, Blocking Peptide (Apoptosis Signal-regulating Kinase 1, ASK-1, Mitogen-activated Protein Kinase Kinase Kinase 5, MAP3K5, MAPKKK5, MAPK/ERK Kinase Kinase 5, MEK Kinase 5, MEKK 5, MEKK5) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | A3795P |
|---|
| Price | |
|---|
| Order / More Info | ASK1, CT, Blocking Peptide from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|