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| Product Name | Phosphoinositide 3-kinase gamma, p110 gamma, catalytically inactive mutant, Recombinant, Human |
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| Description | Purity ≥ 90% by SDS-PAGE. The PI3K D946A protein is a catalytically inactive mutant of PI3K with a D946A mutation in the ATP binding site. This recombinant catalytically inactive protein can be used as a negative control in any kind of PI3K kinase activity studies. Recombinant full length PI3K DA mutant carries a N-terminal GST-Tag and was purified by affinity chromatography. The GST-Tag facilitates the protein's application in typical GST pull-down assays. Phosphoinositide 3-kinases (PI3Ks) phosphorylate (PIs) at their 3?-OH position generating lipid second messengers and thereby regulate numerous biological processes including cell growth, differentiation, survival, proliferation, migration and metabolism. On the basis of structural similarities and substrate specificity, the PI3K family can be subdivided into three classes termed I, II, and III. All human class I members are heterodimers consisting of a catalytic subunit (MW approx. 110kD) and a noncatalytic subunit (MW 50, 55, 85, |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Phosphoinositide 3-kinase gamma, p110 gamma, catalytically inactive mutant, Recombinant, Human (PI3K) |
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| Gene, Accession, CAS # | Accession: NM_002649, NP_002640 |
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| Catalog # | P4073-35F |
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| Order / More Info | Phosphoinositide 3-kinase gamma, p110 gamma, catalytically inactive mutant, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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