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| Product Name | Phosphoinositide 3-kinase p110 alpha, p85 alpha, Active, Recombinant, Human, FLAG-Tag |
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| Description | Purified (~55%). PI3K plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3K into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor It was also shown that PI3K mediated phosphorylation of the p85 adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3'-phosphorylated phosphoinositides. PI3K is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3K activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation. The PI3K catalytic and regulatory subunits are coexpressed in Sf9 insect cells. Phosphoinositide 3-kinases (PI3Ks) phosphorylate phosphatidylinositols (PIs) at their 3?-OH position generating lipid second messengers and thereby regulate numerous biological processes incl |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Phosphoinositide 3-kinase p110 alpha, p85 alpha, Active, Recombinant, Human, FLAG-Tag (PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform, PI3-kinase Subunit Alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase Subunit Alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110kD Catalytic Subunit Alpha, PtdIns-3-kinase Subunit p110-alpha, Phosphoinositide-3-kinase Catalytic Alpha Polypeptide, Serine/Threonine Protein Kinase PIK3CA/PIK3R1, Phosphatidylinositol 3-kinase Regulatory Subunit Alpha, PI3-kinase Regulatory Subunit Alpha, PI3K Regulatory Subunit Alpha, PtdIns-3-kinase Regulatory Subunit Alpha, Phosphatidylinositol 3-kinase 85kD Regulatory Subunit Alpha, PI3-kinase Subunit p85-alpha, PtdIns-3-kinase Regulatory Subunit p85-alpha, GRB1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137356 |
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| Order / More Info | Phosphoinositide 3-kinase p110 alpha, p85 alpha, Active, Recombinant, Human, FLAG-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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