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| Product Name | Maspin, Recombinant, Human (Mammary-specific Serpin, SERPINB5, Protease inhibitor 5) |
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| Description | Purity ≥ 90% by SDS-PAGE gel and HPLC analyses. Endotoxin:≤0.1ng/ug (1EU/ug). Maspin or mammary-specific serpin is a tumor suppressor protein of serine proteinase inhibitor family. Its transcription is regulated in combinatorial fashion by Ets, p53 and AP-1. It is present in normal breast and prostatic epithelial cells but downregulated in the respective carcinomas. The extent of downregulation correlates with the progression of the carcinoma and may help in prognosis. Maspin has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the ability of Maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells. Recombinant human Maspin is a 42.2kD non-glycosylated protein containing 375 amino acid residues. AA Sequence: MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDL |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: U04313 |
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| Catalog # | M2412-50C |
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| Order / More Info | Maspin, Recombinant, Human (Mammary-specific Serpin, SERPINB5, Protease inhibitor 5) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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