| 产品详情 |
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| Product Name | Ruxolitinib |
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| Description | A potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | INCB 018424 |
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| Gene, Accession, CAS # | CAS: 941678-49-5 |
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| Catalog # | 11609-25 |
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| Price | |
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| Order / More Info | Ruxolitinib from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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