| 产品详情 |
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| Product Name | Casticin |
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| Description | Purity >98%. Casticin is a flavonol isolated from A. annua, V. trifolia, and V. agnus-castus that decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cell lines (IC50 s = 5.95, 4.82, and 15.56 µM, respectively). It blocks TGF-Beta/SMAD signaling in LX2 cells preventing activation, inhibiting proliferation, and inducing apoptosis of these hepatic stellate cells. In a mouse model of liver fibrosis, casticin (20 mg/kg) decreases TGF-Beta1 mRNA and phosphorylated SMAD (p-SMAD) levels. Casticin induces apoptosis in hepatocellular carcinoma (HCC) and breast cancer cells. It also downregulates Twist and prevents the epithelial-mesenchymal transition (EMT) in human HCC SMMC-7721 cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one, Vitexicarpin |
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| Gene, Accession, CAS # | CAS: 479-91-4 |
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| Catalog # | LS-H7013 |
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| Order / More Info | Casticin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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