| 产品详情 |
| Edit |   |
|---|
| Product Name | NCBP2, Recombinant, Human, aa1-156, GST-Tag (Nuclear Cap-Binding Protein Subunit 2) |
|---|
| Description | Purity ~90% (SDS-PAGE). Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC com |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 20kD nuclear cap-binding protein Cell proliferation-inducing gene 55 protein NCBP 20kD subunit |
|---|
| Gene, Accession, CAS # | SwissProt: P52298 |
|---|
| Catalog # | 374379 |
|---|
| Price | |
|---|
| Order / More Info | NCBP2, Recombinant, Human, aa1-156, GST-Tag (Nuclear Cap-Binding Protein Subunit 2) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|