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| Product Name | Quinacrine (hydrochloride hydrate) |
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| Description | Purity >95%. Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for DNA and RNA in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells. It has anti-protozoal properties, potently prevents misfolding of prion protein (EC50 = 0.3 µM), blocks voltage-dependent sodium channels (IC50 = 3.3 µM), and inhibits aldehyde oxidase (IC50 = 3.3 µM). Quinacrine is also an effective riboflavin antagonist, associating with the riboflavin-binding protein (Ki = 6.7 µM), and an inhibitor of P-glycoprotein (EC50 = 14.4 µM). At much higher doses, quinacrine inhibits phospholipase A2 activity. Quinacrine binds to nucleic acids and has been used in fixed cells to stain DNA and RNA with excitation/emission maxima of 436/525 nm, respectively. In live cells, it is taken up into acidic vesicles, such as lysosomes, and can be used to for long-term imaging with an excitation of 458 nm and emission in the 470-580 nm range. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N4 -(6-chloro-2-methoxyacridin-9-yl)-N1 ,N1 -diethylpentane-1,4-diamine, dihydrochloride hydrate, Atebrine, Mepacrine |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H9627 |
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| Order / More Info | Quinacrine (hydrochloride hydrate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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