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| Product Name | BRCC3, Recombinant, Human, aa2-316, His-GST-Tag (Lys-63-specific Deubiquitinase BRCC36) |
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| Description | Purity ~85% (SDS-PAGE). Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically roves 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. Source: Recombinant protein corresponding to aa2-316 from human BRCC3, fused to His-GST-Tag at N-terminal, expressed |
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| Size | 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P46736 |
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| Catalog # | 370547 |
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| Order / More Info | BRCC3, Recombinant, Human, aa2-316, His-GST-Tag (Lys-63-specific Deubiquitinase BRCC36) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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