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| Product Name | B-Cell Activating Factor, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). The B cell-activating factor from the TNF family (BAFF), is emerging as an important regulator of B cell and T cell responses. BAFF was originally identified as a factor responsible for B cell survival and maturation. BAFF binds to several receptors. These include transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), BAFF-R (BR3), and B cell maturation Ag (BCMA). BAFF-R appears to be particularly important for the regulation of B cell survival and maturation in the spleen, because A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice. Source: Recombinant protein corresponding to human B-Cell Activating Factor expressed in E. coli. Molecular Weight: ~18kD Biological Activity: The ED50 was determined by a cell proliferation assay using anti-IgM stimulated murine B cells, and is ≤2ng/ml. Specific Activity: 5x10e5IU/mg. Endotoxin: <1EU/ug (LAL) |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | B-Cell Activating Factor, Recombinant, Human (B Cell Activating Factor belonging to the TNF Family, BAFF, Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, TNFSF20, B Lymphocyte Stimulator, BLys, THANK, Dendritic Cell-Derived TNF-Like Molecule, TNF- and APOL-Related Leukocyte Expressed Ligand 1, TALL-1, CD_Antigen=CD257) |
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| Gene, Accession, CAS # | SwissProt: Q9Y275 |
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| Catalog # | 499798 |
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| Order / More Info | B-Cell Activating Factor, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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