| 产品详情 |
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| Product Name | Aftin-4 |
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| Description | Purity >98% by NMR. A Roscovitine-related purine derivative that selectively and potently increases production of extracellular ABeta42 and decreases production of extracellular ABeta38 in cultured cells. Extracellular ABeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting Gamma-secretase activity toward ABeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. An amyloid-Beta42 Inducer. (Biochemical) |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N6-Methyl-(R)-roscovitine, Amyloid-β Forty-Two Inducer 4 |
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| Gene, Accession, CAS # | CAS: 866893-90-5 |
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| Catalog # | LS-H3141 |
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| Order / More Info | Aftin-4 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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