| 产品详情 |
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| Product Name | Aftin-5 |
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| Description | Purity ~98% (NMR). Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Ab42 and decreases production of extracellular Ab38 in cultured cells. Extracellular Ab40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Ab42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Formula: C19H26N6O Solubility: DMSO or ethanol Molecular Weight: ~354.5 |
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| Size | 1mg, 5mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Aftin-5 ((2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol, Amyloidbeta Forty-Two Inducer 5) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207036 |
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| Price | |
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| Order / More Info | Aftin-5 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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