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| Product Name | Macrophage Inflammatory Protein-1 beta, Recombinant, Human (CCL4) |
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| Description | Purity ~99% (RP-HPLC, SDS-PAGE). Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now also named CCL3 and CCL4. Both factors are produced by macrophages after they are stimulated with bacterial endotoxins. MIP-1a and MIP-1b activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. MIP-1a and MIP-1b induce synthesis and release of other pro- inflammatory cytokines such as interleukin-1 (IL-1), IL-6 and TNF-alpha from fibroblasts and macrophages. CCL3 and CCL4 genes are both located on human chromosome 17. Source: Recombinant protein corresponding to a single, non-glycosylated, polypeptide chain containing 69aa from human MIP-1b, expressed in E. coli. Molecular Weight: ~7.6kD Biological Activity: Calculated by the ability to chemoattract human blood monocytes using a concentration of 5-20ng/ml. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209077 |
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| Order / More Info | Macrophage Inflammatory Protein-1 beta, Recombinant, Human (CCL4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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