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| Product Name | Membrane Frizzled-Related Protein, Recombinant, Human |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤1EU/ug (LAL). MFRP (membrane-type frizzled-related protein) is a 65kD, type II transmembrane protein related to both Tolloid proteases and frizzled-domain containing Wnt pathway proteins (1-4). Human MFRP is 579 amino acids (aa) in length (3, 5, 6). It contains a 69aa cytoplasmic region, a 21aa transmembrane segment, and a 489aa extracellular domain (ECD). The ECD is characterized by the presence of two LDLR class A repeats, two CUB domains, and a C-terminal cysteine-rich/frizzled domain. The mRNA for MFRP is highly unusual in that it is dicistronic; that is, it contains two independent ORFs, one for MFRP and one for a functionally- related protein termed CTRP5/C1qTNF5 (4, 7). CTRP5 is a secreted, 25kD short-chain collagen that contains a C1q-type domain (6, 8). In prokaryotes, polycistronic transcripts exist that contain functionally-interactive molecules. This would also appear to be the case for MFRP |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Membrane Frizzled-Related Protein, Recombinant, Human (Membrane-type Frizzled-Related Protein, MFRP) |
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| Gene, Accession, CAS # | Gene ID: 83552, SwissProt: Q9BY79 |
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| Catalog # | M2873-03A |
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| Order / More Info | Membrane Frizzled-Related Protein, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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