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| Product Name | p-Glycoprotein, Recombinant, Human, aa1036-1280, His-Tag |
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| Description | Highly Purified (~95%). P-glycoprotein 1 (permeability glycoprotein, P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood-brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also |
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| Size | 2ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | p-Glycoprotein, Recombinant, Human, aa1036-1280, His-Tag (Pgp, Multidrug Resistance Protein 1, MDR1, ATP-binding Cassette Sub-family B Member 1, ABCB1, Cluster of Differentiation 243, CD243) |
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| Gene, Accession, CAS # | SwissProt: P08183 |
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| Catalog # | 209127 |
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| Order / More Info | p-Glycoprotein, Recombinant, Human, aa1036-1280, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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