| 产品详情 |
| Edit |   |
|---|
| Product Name | GW 4869 (hydrochloride hydrate) |
|---|
| Description | Purity >90%. Neutral sphingomyelinases mediate the release of ceramide from sphingomyelin in cellular membranes and can be activated by certain stresses. Ceramide can act as a signaling molecule in its own right, or it can be further processed to generate sphingosine (and sphingosine-1-phosphate). GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 µM), but does not affect acid sphingomyelinase activity. It inhibits TNF-Alpha-mediated sphingomyelin hydrolysis (100% inhibition at 20 µM) 1 and TNF-Alpha-induced cell death in MCF-7 cells without interfering with activation of NF-?B or glutathione depletion in response to TNF. GW 4869 also reduces the inhibitory effect of oxidized phospholipid products on lipopolysaccharides-mediated induction of interleukin-8 in human aortic endothelial cells 3 and prevents hypoxia-induced pulmonary vasoconstriction in rats in vivo . |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 3,3'-(1,4-phenylene)bis [N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-dihydrochloride-2-propenamide |
|---|
| Gene, Accession, CAS # | CAS: 6823-69-4 |
|---|
| Catalog # | LS-H8049 |
|---|
| Price | |
|---|
| Order / More Info | GW 4869 (hydrochloride hydrate) from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|