| 产品详情 |
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| Product Name | AZD6482 |
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| Description | Purity >98%. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3 . PI3KAlpha, Beta, and Delta are class 1A enzymes composed of p110 and p85 subunits, whereas PI3KGamma is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. AZD6482 is a PI3K inhibitor that targets the Beta isoform more potently than PI3KDelta, PI3KGamma, or PI3KAlpha (IC50 s = 0.69, 13.6, 47.8, and 136 nM, respectively). It displays 80-fold selectivity for PI3KBeta over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases. AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3KBeta activation or PTEN loss. AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice. It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-benzoic acid, KIN-193 |
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| Gene, Accession, CAS # | CAS: 1173900-33-8 |
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| Catalog # | LS-H6715 |
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| Order / More Info | AZD6482 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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