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| Product Name | PAFAH, Recombinant, Human |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet Activating Factor Acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the sn2 ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. Recombinant PAF-AH is a 420aa glycoprotein which migrates with an apparent molecular mass of 47-55kD by SDS-PAGE analysis. Biological Activity: Measured by its ability to cleave a PAF analog in a chromogenic substrate linked assay. At a PAF-AH concentration of 10ug/ml, 50% cleavage was achieved at an i |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PAFAH, Recombinant, Human (Platelet-activating Factor Acetylhydrolase, PAF Acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine Esterase, 2-acetyl-1-alkylglycerophosphocholine Esterase, Group-VIIA Phospholipase A2, gVIIA-PLA2, LDL-associated Phospholipase A2, LDL-PLA(2), PAF 2-acylhydrolase, PLA2G7) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143462 |
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| Order / More Info | PAFAH, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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