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| Product Name | PLCD4, Recombinant, Human, aa1-762, His-SUMO-tag |
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| Description | Purity ~90% (SDS-PAGE). PLCD4, Recombinant, Human, aa1-762, His-SUMO-Tag (1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase delta-4). Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. Source: Recombinant protein corresponding to aa1-762 from human PLCD4, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~103.6kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Phosphoinositide phospholipase C-delta-4,Phospholipase C-delta-4, PLC-delta-4 |
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| Gene, Accession, CAS # | SwissProt: Q9BRC7 |
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| Catalog # | 374744 |
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| Order / More Info | PLCD4, Recombinant, Human, aa1-762, His-SUMO-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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