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| Product Name | CZC-54252 |
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| Description | Purity >98% by NMR, TLC. CZC-54252 is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM). The G2019S mutant is a common mutation found in familial Parkinson's disease patients. Cell permeable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[[[5-Chloro-2-[[2-methoxy-4-(4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-phenyl]methanesulfonamide hydrochloride |
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| Gene, Accession, CAS # | CAS: 1191911-27-9 |
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| Catalog # | LS-H14644 |
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| Order / More Info | CZC-54252 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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