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| Product Name | Histone H3, trimethyl (Lys4) Blocking Peptide |
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| Description | Highly Purified. Peptide is used to block Tri-MethylHistone H3 (Lys4) Rabbit mAb and Tri-Methyl-Histone H3 (Lys4) Antibody reactivity in immunohistochemistry protocols. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. Originally thought to function as a static scaffold for DNA packaging, histones have now been shown to be dynamic proteins, undergoing multiple types of post-translational modifications, including acetylation, phosphorylation, methylation and ubiquitination (1). Histone methylation is a major determinant for the formation of active and inactive regions of the genome and is crucial for the proper programming of the genome during development (2,3). Arginine methylation of histones H3 (Arg2, 17, 26) and H4 (Arg3) promotes transcriptional activation and is mediated by a family of protein arginine methyltransferases (PRMTs), including the co-activators PRMT1 and CARM1 (PRMT4) (4). In contrast, a more diver |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | IHC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H5110-14S2 |
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| Order / More Info | Histone H3, trimethyl (Lys4) Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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