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| Product Name | S100-A8, Recombinant, Mouse, aa2-89, His-Tag (Protein S100a8) |
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| Description | Purity ~85% (SDS-PAGE). S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and Extracellular domain functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The Extracellular domain functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Calgranulin-A Chemotactic cytokine CP-10 Leukocyte L1 complex, light chain; Migration inhibitory factor-related protein 8, MRP-8, p8 Pro-inflammatory S100 cytokine, S100 calcium-binding protein A8 |
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| Gene, Accession, CAS # | SwissProt: P27005 |
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| Catalog # | 375175 |
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| Order / More Info | S100-A8, Recombinant, Mouse, aa2-89, His-Tag (Protein S100a8) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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