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| Product Name | PAK4, Recombinant, Human, aa1-426, His-SUMO-Tag (Serine/threonine-protein Kinase PAK 4) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | p21-activated kinase 4, PAK-4 |
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| Gene, Accession, CAS # | SwissProt: O96013 |
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| Catalog # | 374602 |
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| Order / More Info | PAK4, Recombinant, Human, aa1-426, His-SUMO-Tag (Serine/threonine-protein Kinase PAK 4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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