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| Product Name | AMICA, Fc Chimera, Recombinant, Mouse |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. AMICA, also known as JAML, is a 65kD, type I transmembrane glycoprotein that belongs to the junctional adhesion molecule (JAM) subset of the immunoglobulin superfamily (1). JAM family proteins contribute to intercellular connections within epithelial and endothelial cell layers and mediate their interactions with various hemopoietic cells (1). The mouse AMICA cDNA encodes a 379 aa precursor that includes a 20 aa signal sequence, a 261 aa extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 77 aa cytoplasmic domain (2). In contrast to other JAM family proteins, AMICA does not contain a cytoplasmic PDZ-binding motif (3). Within the ECD, mouse AMICA shares 58% and 77% aa sequence identity with human and rat AMICA, respectively. It shares 17%-23% aa sequence identity with the ECDs of mouse JAM-A, -B, -C, and JAM4. AMICA is expressed on the surface of granulocytes and monocytes and i |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AMICA, Fc Chimera, Recombinant, Mouse (Adhesion Molecule that Interacts with CXADR Antigen 1, Junction Adhesion Molecule-Like, JAM-L, JAML) |
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| Gene, Accession, CAS # | SwissProt: Q80UL9 |
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| Catalog # | A1372-31 |
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| Order / More Info | AMICA, Fc Chimera, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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