| 产品详情 |
| Edit |   |
|---|
| Product Name | Heat Shock Cognate Protein 70, Recombinant, Rat |
|---|
| Description | Purity ≥ 85% as determined by SDS-PAGE analysis. Hsc70-interacting protein (Hip) is a cytosolic protein that exists as a homo-oligomer and participates in the regulation of the heat shock protein Hsc70 in eukaryotic cells (1). Hip interacts with the ATPase domain of Hsc70 molecules through the tetratricopeptide repeats and flanking charged α-helices of Hip (2). This binding reaction is dependent on Hsp40 in the presence of ATP and becomes Hsp40-independent if Hsc70 is preincubated with ADP (2). Upon binding to Hsc70, Hip stabilizes the ADP-bound state of Hsc70, a conformation that has a high affinity for unfolded substrate proteins. Hip by itself binds unfolded polypeptides, suggesting that it may possess chaperone activity (2,3). Together with Hsp40, Hip may regulate the chaperone activity of Hsc70 by stabilizing the chaperone-substrate complex. Rat Hip has a carboxyl terminal addition of residues GSEQKLISEEDL, which represents glycine and serine residues followed by amino acids |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Heat Shock Cognate Protein 70, Recombinant, Rat (Hsc70-interacting protein, Hip, HSC70, Heat Shock Protein 73, HSP73) |
|---|
| Gene, Accession, CAS # | SwissProt: P50503 |
|---|
| Catalog # | H1830-25C |
|---|
| Price | |
|---|
| Order / More Info | Heat Shock Cognate Protein 70, Recombinant, Rat from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|