| 产品详情 |
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| Product Name | Heat Shock Factor 1 Inhibitor, KRIBB11 |
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| Description | Purity ~95% (HPLC). A cell-permeable 2,6-diaminopyridine compound that directly binds HSF1 and reversibly inhibits its transcriptional activity (IC50=1.2uM in heat shocked p[HSE]4-Ta-Luc transfected HCT-116 cells), and suppresses both the transcription and expression of hsp70, hsp47 and hsp27. Shown to block heat shock-induced p-TEFb (positive transcription elongation factor b) recruitment to the hsp70 promoter and inhibit the phosphorylation of RNA Pol II CTD-Ser2 with no effect on TNF-a-stimulated NF-kB activity in HeLa cells. Induces G2/M growth arrest and apoptosis (IC50 ~5uM in HCT-116 cells), and further decreases tumor growth in mouse xenograft regression model (50mg/kg, i.p.). Formula: C13H12N6O2 Molecular Weight: 284.3 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Heat Shock Factor 1 Inhibitor, KRIBB11 (N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor, Hsp70 Induction Inhibitor II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217416 |
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| Order / More Info | Heat Shock Factor 1 Inhibitor, KRIBB11 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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