| 产品详情 |
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| Product Name | TAK-733 |
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| Description | Purity >98%. TAK-733 is an inhibitor of MEK1 (IC50 = 3.2 nM), a MAP kinase in the Raf/MEK/ERK pathway that plays a major role in the regulation of cellular growth, differentiation, and proliferation. It is selective for MEK1 over a panel of 18 kinases, receptors, and ion channels up to a concentration of 10 µM. TAK-733 inhibits ERK phosphorylation in vitro (EC50 = 1.9 nM). It also inhibits proliferation of A375 and COLO 205 cells (EC50 s = 3.1 and 2.1 nM, respectively) and 14 cutaneous melanoma cell lines (IC50 s = <1-10 nM), particularly those with B-RAFV600E mutations. TAK-733 has antitumor activity in mouse xenograft models using a variety of cancer types. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione |
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| Gene, Accession, CAS # | CAS: 1035555-63-5 |
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| Catalog # | LS-H10094 |
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| Price | |
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| Order / More Info | TAK-733 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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