| 产品详情 |
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| Product Name | Gambogic Acid |
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| Description | Purity >95%. Gambogic acid (GA) is a natural product isolated from the G. hanburyi tree that exhibits anti-cancer activity by acting on a variety of cellular pathways. In the apoptotic pathway, GA activates caspases (EC50 = 0.78 µM), inhibits binding of anti-apoptotic proteins to a BH3 peptide (IC50 = 1.47, 1.21, 2.02, 0.66, 1.06, 0.79 µM for Bcl-xL, Bcl-2, Bcl-W, Bcl-B, Bfl-1, Mcl-1, respectively), and alters expression of Bcl-2 and Bax. GA binds to the transferrin receptor (IC50 = 4.1 µM), inducing apoptosis in various tumor cell lines. It is a potent, slow inhibitor of Kir 2.1 channels (IC50 = <100 nM). GA inhibits the chymotrypsin activity of the 20S proteasome in a dose-dependent manner. A novel mechanism for GA cytotoxic effects in glioma cells may be through AMPK-initiated effects on EGFR and Akt/mTORC1 signaling. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2Z-butenoic acid, GA, -Beta-Guttiferin |
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| Gene, Accession, CAS # | CAS: 2752-65-0 |
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| Catalog # | LS-H7894 |
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| Order / More Info | Gambogic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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