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| Product Name | Fibroblast Growth Factor 21, Recombinant, Mouse (FGF-21, Fgf21) |
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| Description | Purity ~95% (SDS-PAGE, HPLC). The FGFs are a family of more than 20 small (~17-26kD) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. FGFR-2 appears to be a key molecule during pancreatic development and FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis. FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when ov |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9JJN1 |
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| Catalog # | F4212-93J |
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| Order / More Info | Fibroblast Growth Factor 21, Recombinant, Mouse (FGF-21, Fgf21) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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