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| Product Name | JAK2, Recombinant, Human, aa752-1132, His-Tag (Tyrosine-Protein Kinase) |
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| Description | Purity ~90% (SDS-PAGE). Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the Cytoplasmic domain tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 au |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Janus kinase 2, JAK-2 |
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| Gene, Accession, CAS # | SwissProt: O60674 |
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| Catalog # | 373886 |
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| Order / More Info | JAK2, Recombinant, Human, aa752-1132, His-Tag (Tyrosine-Protein Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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