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| Product Name | JAK3, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease). Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow. Source: Recombinant protein corresponding to human JAK3, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~64kD Specific Activity: 91nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JAK3, Recombinant, Human, GST-Tag (Janus kinase 3, Tyrosine-Protein Kinase Jak3, JAKL, LJAK, JAK-3, L-JAK, JAK3-HUMAN) |
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| Gene, Accession, CAS # | Accession: NM_000215 |
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| Catalog # | 500191 |
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| Order / More Info | JAK3, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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