| 产品详情 |
| Edit |   |
|---|
| Product Name | Caspase-3, Recombinant, Mouse (Casp3, CPP32, Yama, Apopain) |
|---|
| Description | Caspase-3 (also known as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. Caspase-3 exists in cells as an inactive 32kD proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. The processed form of caspase-3 consists of large (17kD) and small (11kD) subunits which associate to form the active enzyme. The active caspase-3 has been shown involving in the proteolysis of several important molecules, such as poly (ADP-ribose) polymerase (PARP), the sterol regulatory element binding proteins (SREBPs), focal adhesion kinase (FAK), and others. The recombinant active human caspase-3 expressed in E. coli spontaneously undergoes autoprocessing to yield subunits characteristic of the native enzyme. The active caspase-3 preferentially cleaves caspase-3 substrates (e.g., DEVD-AFC or DEVD-pNA) and is routinely tested for its ab |
|---|
| Size | 100units |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Active Mouse Caspase-3, Caspase-3 Enzyme, caspase-3, mouse caspase-3, mouse caspases, active caspases, caspase-3 assay positive control |
|---|
| Gene, Accession, CAS # | CASP3, Gene ID: 12367, SwissProt: Q8BNT4 |
|---|
| Catalog # | 219563 |
|---|
| Price | |
|---|
| Order / More Info | Caspase-3, Recombinant, Mouse (Casp3, CPP32, Yama, Apopain) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|