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| Product Name | Autotaxin Inhibitor III, PF-8380 |
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| Description | Purity ~95% (HPLC). An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.). Formula: C22H21Cl2N3O5 Solubility: DMSO Molecular Weight: 478.3 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217206 |
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| Order / More Info | Autotaxin Inhibitor III, PF-8380 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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