| 产品详情 |
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| Product Name | Avagacestat |
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| Description | Purity >98%. Gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and Beta-amyloid precursor protein (APP), within the transmembrane domain. Avagacestat is a potent, orally bioavailable inhibitor of Gamma-secretase that more potently inhibits the cleavage of APP to ABeta40 than signaling through Notch (IC50 s = 0.30 and 58 nM, respectively). It shows good pharmacokinetics in rats, dogs, and humans and passes the blood-brain barrier, reducing plasma, brain, and cerebrospinal fluid ABeta40 levels. While suppressing the production of ABeta38, ABeta40, and ABeta42, Gamma-secretase inhibitors, including avagacestat, increase the level of APP Beta-C-terminal fragment, both in vitro and in vivo, altering cell function. Avagacestat may impact Notch signaling in vivo, although it is generally considered a Notch-sparing Gamma-secretase inhibitor. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-pentanamide, BMS 708163 |
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| Gene, Accession, CAS # | CAS: 1146699-66-2 |
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| Catalog # | LS-H6673 |
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| Order / More Info | Avagacestat from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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