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| Product Name | PDHK3, Recombinant, Human, GST-Tag (Pyruvate Dehydrogenase Kinase 3, PDK3) |
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| Description | Purified (~70-90%). PDHK3 or Pyruvate Dehydrogenase Kinase 3 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH). PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. HIF-1 induces PDHK3 expression leading to inhibition of mitochondrial respiration. Forced expression of PDHK3 in cancer cells results in increased lactic acid accumulation and drugs resistance, whereas knocking down PDHK3 inhibits hypoxia-induced cytoplasmic glycolysis and cell survival. Source: Recombinant protein corresponding to human PDHK3, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~69kD Specific Activity: 12nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_005391 |
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| Catalog # | 500353 |
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| Order / More Info | PDHK3, Recombinant, Human, GST-Tag (Pyruvate Dehydrogenase Kinase 3, PDK3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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