| 产品详情 |
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| Product Name | Picropodophyllotoxin |
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| Description | MW: 414.4. Purity >97% (TLC); NMR (Conforms). IGF1R inhibitorScientific Background: Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP (1). Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM (1). Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 uM (2). Exhibits antiangiogenic activitiy (3). Attenuates intimal hyperplasia after vascular injur |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Vatalanib 2 HCl; (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one] |
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| Gene, Accession, CAS # | CAS: 477-47-4 |
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| Catalog # | MBS515072 |
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| Order / More Info | Picropodophyllotoxin from MYBIOSOURCE INC. |
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| Product Specific References | 1. A Girnita et al. Cancer Res. 2004 64:236 2. A Girnita et al. Clin. Cancer Res. 2006 12:1383 3. E Menu et al. Int. J. Cancer 2007 121:1857 4. A Razuvaev et al. J. Vasc. Surg. 2007 46:108 |
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