| 产品详情 |
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| Product Name | Sunitinib Maleate (Sutent, Sunitinib Malate, SU-11248, PHA-290940AD, PNU-290940AD) |
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| Description | Purity ~90%. A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Sunitinib and its active metabolite (SU012662) are selective inhibitors of multiple receptor tyrosine kinases, including platelet-derived growth factor receptor and vascular endothelial growth factor receptor, that are associated with tumor growth and angiogenesis. Sunitinib dose-dependently inhibited stem cell factor (SCF)-induced phosphotyrosine levels on KIT (IC50 = 1-10nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC50 value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC50 = 2nM). Solubility: Soluble in DMSO. Poorly soluble in dH2O and ethanol. Elemental Analysis: Calculated: C- 58.64% H- 6.25% F- 3.57% N- 10.52% |
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| Size | 100mg, 250mg, 500mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Sutent |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | S8032 |
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| Order / More Info | Sunitinib Maleate (Sutent, Sunitinib Malate, SU-11248, PHA-290940AD, PNU-290940AD) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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