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| Product Name | V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (C-Term), (AA 23-652) protein |
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| Description | Recombinant Human Receptor tyrosine-protein kinase erbB-2/HER2/ERBB2 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Thr23-Thr652) of Human HER2/ERBB2 fused with a FC tag at the C-terminus.. Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-α and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. It is part of a complex with EGFR and either PIK3C2A or PIK3C2B. It may interact with PIK3C2B when phosphorylated on Tyr-1196. The protein also interacts with many proteins such as PRKCABP, PLXNB1, MEMO1, MUC1,GRB7 (via SH2 domain),ERBB2IP,KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94, ACTB, SRC. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1|Erbb-2|Neu|c-erbB2|c-neu|mKIAA3023 |
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| Gene, Accession, CAS # | Gene ID: 2064 |
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| Catalog # | ABIN1691750 |
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| Order / More Info | V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (C-Term), (AA 23-652) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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