| 产品详情 |
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| Product Name | CFI-400945 |
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| Description | Purity >98%. CFI-400945 is an orally available, selective inhibitor of polo-like kinase 4 (PLK4; IC50 = 2.8 nM), a unique kinase that regulates centriole duplication during the cell cycle. It does not inhibit other members of the PLK family (IC50 s > 50 µM for PLK1, PLK2, and PLK3). CFI-400945 has been shown to dysregulate centriole duplication, disrupt mitosis, and induce apoptosis in various PLK4-overexpressing breast cancer cells and to reduce tumor growth in mice bearing MDA-MB-468 breast tumor xenografts. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1S,2R)-2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-spiro[cyclopropane-1,3'-[3 H]indol]-2'(1'H)-one |
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| Gene, Accession, CAS # | CAS: 1338800-06-8 |
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| Catalog # | LS-H7084 |
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| Price | |
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| Order / More Info | CFI-400945 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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