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| Product Name | CYT387 |
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| Description | Purity >98%. CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50 s = 11 and 18 nM, respectively). It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines. It is efficacious in a mouse model of JAK2V617F -dependent myeloproliferative neoplasms, although kinase domain mutations can confer resistance. CYT387 also blocks paclitaxel-induced JAK2 activation in ovarian cancer cells, preventing the development of a cancer stem cell-like population following chemotherapy. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide, Momelotinib |
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| Gene, Accession, CAS # | CAS: 1056634-68-4 |
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| Catalog # | LS-H7316 |
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| Order / More Info | CYT387 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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