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| Product Name | Activin A Receptor Type IB, Recombinant, Mouse |
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| Description | Purity ~90%, as determined by SDS-PAGE and visualized by silver stain. Activin RIB, also known as ALK4, is a glycosylated 58kD type I transmembrane receptor that belongs to the superfamily of TGF-b serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules (1). These ligands bind to Activin RIIB which then associates with, and phosphorylates, the cytoplasmic domain of Activin RIB to initiate signal transduction (2, 3). Mature mouse Activin RIB consists of a 103 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain (4). Within the ECD, mouse Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB, respectively. It shares 23%-38% aa sequence identity with other mouse type I receptors Activin RIA, BMPR-IA, BMPR-IB, and TGF-b RI. Activin receptor signaling is modulated by the direct interaction of Activin RIB with c |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Activin A Receptor Type IB, Recombinant, Mouse (RIB/Fc Chimera, Activin Receptor-like Kinase 4, Activin Receptor Type 1B Precursor, ACTRIB, ACTR-IB, ACVRLK4, ALK4, ALK-4, Serine/threonine-protein Kinase Receptor R2, SKR2) |
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| Gene, Accession, CAS # | Accession: NP_031421 |
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| Catalog # | A0855-90A |
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| Order / More Info | Activin A Receptor Type IB, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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