| 产品详情 |
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| Product Name | Aminoacyl tRNA synthase complex-interacting multifunctional, active 1, active (AIMP1), Recombinant, Human |
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| Description | Purity ≥98% (SDS-PAGE and HPLC). Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. (ECO:0000269|PubMed:10e358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:1223731 |
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| Size | 5ug, 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, EMAP-II, Small i, |
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| Gene, Accession, CAS # | AIMP1_HUMAN, SwissProt: Q12904 |
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| Catalog # | 347928 |
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| Order / More Info | Aminoacyl tRNA synthase complex-interacting multifunctional, active 1, active (AIMP1), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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