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| Product Name | PLK4, Recombinant, Human, GST-Tag (Polo-Like Kinase 4, SAK, STK18) |
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| Description | Purified (~70-90%). PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development. Source: Recombinant protein corresponding to human PLK4, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~140kD Specific Activity: 5.6nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_014264 |
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| Catalog # | 500405 |
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| Order / More Info | PLK4, Recombinant, Human, GST-Tag (Polo-Like Kinase 4, SAK, STK18) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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