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| Product Name | MAPK13, Recombinant, Human, aa1-365, His-SUMO-Tag (Mitogen-activated Protein Kinase 13) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by Extracellular domain stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an i |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: O15264 |
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| Catalog # | 374146 |
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| Order / More Info | MAPK13, Recombinant, Human, aa1-365, His-SUMO-Tag (Mitogen-activated Protein Kinase 13) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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