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| Product Name | MAPK9, Recombinant, Human, aa1-424, His-SUMO-Tag (Mitogen-activated Protein Kinase 9) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular domain stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 ce |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JNK-55, Stress-activated protein kinase 1a, SAPK1a, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2 |
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| Gene, Accession, CAS # | SwissProt: P45984 |
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| Catalog # | 374149 |
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| Order / More Info | MAPK9, Recombinant, Human, aa1-424, His-SUMO-Tag (Mitogen-activated Protein Kinase 9) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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