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| Product Name | MAPK3, Recombinant, Human, aa11-379, His-Tag (Mitogen-activated Protein Kinase 3) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangents. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and se to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ERT2, Extracellular domain signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1 |
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| Gene, Accession, CAS # | SwissProt: P27361 |
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| Catalog # | 374148 |
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| Order / More Info | MAPK3, Recombinant, Human, aa11-379, His-Tag (Mitogen-activated Protein Kinase 3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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