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| Product Name | Map2k4, Recombinant, Mouse, aa2-397, His-SUMO-Tag (Dual Specificity Mitogen-activated Protein Kinase Kinase 4) |
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| Description | Purity ~90% (SDS-PAGE). Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/J |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | C-JUN, N-terminal kinase kinase 1, JNK kinase 1, JNKK 1, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1 |
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| Gene, Accession, CAS # | SwissProt: P47809 |
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| Catalog # | 374142 |
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| Order / More Info | Map2k4, Recombinant, Mouse, aa2-397, His-SUMO-Tag (Dual Specificity Mitogen-activated Protein Kinase Kinase 4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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